Authors
PG Casali, N Abecassis, S Bauer, R Biagini, S Bielack, S Bonvalot, I Boukovinas, JVMG Bovee, T Brodowicz, JM Broto, A Buonadonna, E De Álava, AP Dei Tos, XG Del Muro, P Dileo, M Eriksson, A Fedenko, V Ferraresi, A Ferrari, Stefano Ferrari, AM Frezza, S Gasperoni, H Gelderblom, T Gil, G Grignani, A Gronchi, RL Haas, A Hannu, B Hassan, P Hohenberger, R Issels, H Joensuu, RL Jones, I Judson, P Jutte, S Kaal, B Kasper, K Kopeckova, DA Krákorová, A Le Cesne, I Lugowska, O Merimsky, M Montemurro, MA Pantaleo, R Piana, P Picci, S Piperno-Neumann, AL Pousa, P Reichardt, MH Robinson, P Rutkowski, AA Safwat, P Schöffski, S Sleijfer, S Stacchiotti, K Sundby Hall, M Unk, F Van Coevorden, W Van der Graaf, J Whelan, E Wardelmann, O Zaikova, JY Blay, ESMO Guidelines Committee and EURACAN
Publication date
2018/10/1
Journal
Annals of Oncology
Volume
29
Issue
Supplement_4
Pages
iv68-iv78
Publisher
Oxford University Press
Description
Gastrointestinal stromal tumours (GISTs) are rare tumours, with an estimated unadjusted incidence of around 1/100 000/year [1]. This only covers clinically relevant GISTs, since, if investigated, a much higher number of lesions≤ 1 cm in diameter (microGISTs) can be found at histopathological examination of stomach tissue in middle-aged and elderly individuals.
There is a slight prevalence in males. The median age is around 60–65 years, with a wide range. Occurrence in children is very rare. Paediatric GIST represents a clinically and molecularly distinct subset, marked by female predominance, absence of KIT/platelet-derived growth factor alpha (PDGFRA) mutations, frequent mutations or silencing of the four genes that encode the subunits of the succinate dehydrogenase (SDH) enzyme complex, gastric multicentric location and possible lymph node metastases [2].
Scholar articles
PG Casali, N Abecassis, S Bauer, R Biagini, S Bielack… - Annals of oncology, 2018